MCP-1: Function, regulation, and involvement in disease
S Singh, D Anshita, V Ravichandiran - International immunopharmacology, 2021 - Elsevier
Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …
[HTML][HTML] The role of monocytes and macrophages in acute and acute-on-chronic liver failure
Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …
[HTML][HTML] Functional roles of chemokine receptor CCR2 and its ligands in liver disease
S She, L Ren, P Chen, M Wang, D Chen… - Frontiers in …, 2022 - frontiersin.org
Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …
immune cells within tissues and are critical for the function of the immune system. CCR2 …
The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair
B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …
[HTML][HTML] Redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola - Fibrogenesis & tissue repair, 2008 - Springer
Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …
[PDF][PDF] CCR2 promotes hepatic fibrosis in mice
Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells
(HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of …
(HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of …
[PDF][PDF] An essential role for monocyte chemoattractant protein‐1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
P Mandrekar, A Ambade, A Lim, G Szabo… - …, 2011 - Wiley Online Library
The importance of chemokines in alcoholic liver injury has been implicated. The role of the
chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with …
chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with …
Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-κB–mediated inflammation in macrophages
Rationale: Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the
progression of human atherosclerosis. However, definitive cell type–specific causation …
progression of human atherosclerosis. However, definitive cell type–specific causation …
[HTML][HTML] Functional role of monocytes and macrophages for the inflammatory response in acute liver injury
HW Zimmermann, C Trautwein, F Tacke - Frontiers in physiology, 2012 - frontiersin.org
Different etiologies such as drug toxicity, acute viral hepatitis B, or acetaminophen poisoning
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …
[HTML][HTML] Oxidative stress and antioxidants in hepatic pathogenesis
HL Ha, HJ Shin, MA Feitelson, DY Yu - World journal of …, 2010 - ncbi.nlm.nih.gov
Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic
liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins …
liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins …