Abstract PGC1α‐Related Coactivator (PRC) is a transcriptional coactivator promoting
cytokine expression in vitro in response to mitochondrial injury and oxidative stress …

There is compelling evidence that chemokines are implicated in the development of tissue
inflammation and fibrosis induced by xenobiotics. This chapter reviews recent experimental …

Background: Owing to a highly variable natural course, the benefits of a successful treatment
may be marginal for many hepatitis C patients. Therefore, the ability to discriminate patients …

Liver is a crucial organ in the body for nutrition metabolism and host defense mechanisms.
Particularly, liver is exposed to circulating antigens and endotoxins from the gut microbiota …

Liver regeneration is a complex process that requires the coordinated expression of
cytokines and growth factors. One well-studied model of liver regeneration is partial …

Temporal expression of chemokines is a crucial factor in the regulation of renal
ischemia/reperfusion (I/R) injury and repair. Beside their role in the migration and activation …

Abstract: Pro-inflammatory cytokines play a key role in pathogenesis of obesity and non-
alcoholic fatty liver disease (NAFLD). IL-15 is a pro-inflammatory cytokine, which signals …

Activation of Spermine/spermidine-N1-acetyltransferase (SSAT) leads to DNA damage and
growth 20 arrest in mammalian cells and its ablation reduces the severity of ischemic and …

Methylmercury (MeHg) is a potent neurotoxin, and human beings are mainly exposed to this
pollutant through fish consumption. We addressed the question of whether a diet mimicking …