[HTML][HTML] Macrophage migration inhibitor factor upregulates MCP-1 expression in an autocrine manner in hepatocytes during acute mouse liver injury
J Xie, L Yang, L Tian, W Li, L Yang, L Li - Scientific reports, 2016 - nature.com
Macrophage migration inhibitor factor (MIF), a multipotent innate immune mediator, is an
upstream component of the inflammatory cascade in diseases such as liver disease …
upstream component of the inflammatory cascade in diseases such as liver disease …
Troxerutin Protects the Mouse Liver against Oxidative Stress-Mediated Injury Induced by d-Galactose
Z Zhang, S Fan, Y Zheng, J Lu, D Wu… - Journal of agricultural …, 2009 - ACS Publications
Troxerutin, a trihydroxyethylated derivative of rutin, has been well-demonstrated to exert
hepatoprotective properties. In the present study, we attempted to explore whether the …
hepatoprotective properties. In the present study, we attempted to explore whether the …
[HTML][HTML] Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline
M McMillin, G Frampton, M Thompson… - Journal of …, 2014 - Springer
Background Acute liver failure leads to systemic complications with one of the most
dangerous being a decline in neurological function, termed hepatic encephalopathy …
dangerous being a decline in neurological function, termed hepatic encephalopathy …
[HTML][HTML] Liver X receptors regulate hepatic F4/80+ CD11b+ Kupffer cells/macrophages and innate immune responses in mice
K Endo-Umeda, H Nakashima, S Komine-Aizawa… - Scientific reports, 2018 - nature.com
The liver X receptors (LXRs), LXRα and LXRβ, are nuclear receptors that regulate lipid
homeostasis. LXRs also regulate inflammatory responses in cultured macrophages …
homeostasis. LXRs also regulate inflammatory responses in cultured macrophages …
Innate immune cells orchestrate the repair of sterile injury in the liver and beyond
There is a close association between inflammation and sterile injury, however not all sterile
injuries are the same. While a regulated inflammatory response is crucial for proper healing …
injuries are the same. While a regulated inflammatory response is crucial for proper healing …
Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis
S Galastri, E Zamara, S Milani, E Novo… - Clinical …, 2012 - portlandpress.com
Expression of CCL2 (CC chemokine ligand 2)(or monocyte chemoattractant protein-1)
regulates inflammatory cell infiltration in the liver and adipose tissue, favouring steatosis …
regulates inflammatory cell infiltration in the liver and adipose tissue, favouring steatosis …
[HTML][HTML] The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola - Fibrogenesis & Tissue Repair, 2012 - Springer
Under physiological conditions, intracellular and tissue levels of reactive oxygen species
(ROS) are carefully controlled and employed as fine modulators of signal transduction, gene …
(ROS) are carefully controlled and employed as fine modulators of signal transduction, gene …
[PDF][PDF] Disruption of the 12/15‐lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease
M Martínez‐Clemente, N Ferré, E Titos, R Horrillo… - …, 2010 - Wiley Online Library
We have shown that Alox15, the gene encoding for 12/15‐lipoxygenase (12/15‐LO), is
markedly up‐regulated in livers from apolipoprotein E‐deficient (ApoE−/−) mice, which …
markedly up‐regulated in livers from apolipoprotein E‐deficient (ApoE−/−) mice, which …
Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols
N Ferre, M Martinez-Clemente… - American Journal …, 2009 - journals.physiology.org
The contribution of metabolic factors to the severity of liver disease is not completely
understood. In this study, apolipoprotein E-deficient (ApoE−/−) mice were evaluated to …
understood. In this study, apolipoprotein E-deficient (ApoE−/−) mice were evaluated to …
Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis
K Rombouts, F Marra - Digestive diseases, 2010 - karger.com
Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in
Western countries. The more severe form of this condition, non-alcoholic steatohepatitis …
Western countries. The more severe form of this condition, non-alcoholic steatohepatitis …