Macrophage migration inhibitor factor (MIF), a multipotent innate immune mediator, is an
upstream component of the inflammatory cascade in diseases such as liver disease …

Troxerutin, a trihydroxyethylated derivative of rutin, has been well-demonstrated to exert
hepatoprotective properties. In the present study, we attempted to explore whether the …

Background Acute liver failure leads to systemic complications with one of the most
dangerous being a decline in neurological function, termed hepatic encephalopathy …

The liver X receptors (LXRs), LXRα and LXRβ, are nuclear receptors that regulate lipid
homeostasis. LXRs also regulate inflammatory responses in cultured macrophages …

There is a close association between inflammation and sterile injury, however not all sterile
injuries are the same. While a regulated inflammatory response is crucial for proper healing …

Expression of CCL2 (CC chemokine ligand 2)(or monocyte chemoattractant protein-1)
regulates inflammatory cell infiltration in the liver and adipose tissue, favouring steatosis …

Under physiological conditions, intracellular and tissue levels of reactive oxygen species
(ROS) are carefully controlled and employed as fine modulators of signal transduction, gene …

We have shown that Alox15, the gene encoding for 12/15‐lipoxygenase (12/15‐LO), is
markedly up‐regulated in livers from apolipoprotein E‐deficient (ApoE−/−) mice, which …

The contribution of metabolic factors to the severity of liver disease is not completely
understood. In this study, apolipoprotein E-deficient (ApoE−/−) mice were evaluated to …

Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in
Western countries. The more severe form of this condition, non-alcoholic steatohepatitis …