The pathogenesis of nonalcoholic steatohepatitis (NASH) is not fully understood, but many
studies have suggested that oxidative stress plays a key role. The methionine-and choline …

Chronic liver disease incidence is increasing among children worldwide due to a multitude
of epidemiological changes. Most of these chronic insults to the pediatric liver progress to …

Previous studies have reported that inflammatory cytokine levels increase in the intraocular
fluids (aqueous humor and vitreous) of highly myopic eyes, However, there has been …

Matrine (Mat) is a major alkaloid extracted from Sophora flavescens Ait, an herb which is
used in the traditional Chinese medicine for treatment of inflammation, cancer, and other …

Aim: To compare hepatic gene expression during the development of experimental biliary
atresia (BA) in two different mouse strains. Methods: Balb/c mice and C57Black/6 (Black/6) …

Background Liver regeneration following 70% partial hepatectomy (PH) requires the
coordinated expression of soluble mediators produced by macrophages. Monocyte …

Background Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan
synthesized by three different enzymes, hyaluronan synthase (HAS) 1, 2, and 3. HA …

Macrophages and myofibroblasts are important in fibrogenesis. The cellular characteristics
in pancreatic fibrosis remain to be investigated. Pancreatic fibrosis was induced in F344 rats …

Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) and Kupffer
cells (KCs) leads to liver fibrosis. Here, we aimed to investigate the molecular mechanism …

As liver biopsy in children poses inherent risks, noninvasive measures of liver fibrosis are
needed. This was a cross-sectional, liver biopsy validation pilot study of 16 participants …