CCR2 and CCR5 promote diclofenac-induced hepatotoxicity in mice

Z He, G Wei, N Li, M Niu, S Gong, G Wu… - Naunyn-Schmiedeberg's …, 2019 - Springer
Liver injury, one of the major side effects of diclofenac (DIC), plagues thousands of patients
who treated with it. Although involvements of metabolic factors, oxidative stress, and …

Tanshinol A ameliorates triton‐1339W‐induced hyperlipidemia and liver injury in C57bl/6J mice by regulating mRNA expression of lipemic‐oxidative injury genes

Y Li, Y Chen, X Huang, D Huang, H Gan, N Yao, Z Hu… - Lipids, 2020 - Wiley Online Library
Tanshinol A, which is derived from a traditional Chinese herbal Radix Salviae Miltiorrhizae
is indicative of a hypolipidemic candidate. Therefore, we aim to validate its hypolipidemic …

[HTML][HTML] Comparison of cytokine levels in prostatic secretion between the IIIa and IIIb subtypes of prostatitis

CL Han, YX Deng, P Hu, BT Hu, T Wang… - Asian Journal of …, 2024 - journals.lww.com
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), also known as National
Institutes of Health (NIH) type III prostatitis, is a common disorder with an unclear etiology …

Inflammatory genes in rat livers from cardiac-and brain death donors

TC Saat, D Susa, NFM Kok, S van den Engel… - journal of surgical …, 2015 - Elsevier
Background Liver transplantation (LT) is the only life-saving treatment for patients with end-
stage liver disease. The increase in patients has prompted the use of not only donation after …

The role of cytokines in the mechanism of adverse drug reactions

MJ Masson, LA Collins, LR Pohl - Adverse Drug Reactions, 2010 - Springer
Cytokines are thought to play a role in acute and/or immune-mediated adverse drug
reactions (ADRs) due to their ability to regulate the innate and adaptive immune systems …

[HTML][HTML] Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl4-treated mice

XL Wang, DW Jia, HY Liu, XF Yan, TJ Ye… - World Journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To investigate the cellular mechanisms of action of Yiguanjian (YGJ) decoction in
treatment of chronic hepatic injury. METHODS: One group of mice was irradiated, and …

Slowly progressive cholangiofibrosis induced in rats by α-naphthylisothiocyanate (ANIT), with particular references to characteristics of macrophages and …

HM Golbar, T Izawa, C Ichikawa, M Tanaka… - Experimental and …, 2013 - Elsevier
A progressive cholangiofibrosis was developed as an animal model in 6-week-old male
F344 rats by repeated intraperitoneal injections of α-naphthylisothiocyanate (ANIT) for 19 …

Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infection

A Demoule, M Divangahi, L Yahiaoui… - Mediators of …, 2009 - Wiley Online Library
Sepsis‐induced diaphragmatic inflammation has been associated with respiratory failure,
but the role of chemokines in this process has not been evaluated. Here we sought to study …

Oxidative stress and liver inflammation

SN Greenhalgh, AI Thompson, NC Henderson… - Studies on Hepatic …, 2015 - Springer
The inflammatory response is of prime importance in liver disease, irrespective of inciting
cause, and is inextricably linked to oxidative stress and the generation of reactive oxygen …

A mouse model linking viral hepatitis and salivary gland dysfunction

LM Kasman, LL London, SD London… - Oral Diseases, 2009 - Wiley Online Library
Objective: Viral hepatitis is known to cause xerostomia in humans, but this has not been
reported in an animal model. We report a severe, acute, highly reproducible saliva …