Chronic myeloid leukemia (CML), a myeloproliferative neoplasm defined by the t (9;
22)(q34; q11) chromosomal translocation, primarily affects older adults. Historically, effective …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm defined by the
chromosomal translocation t (9; 22)(q34; q11), which fuses the BCR and ABL genes to …

Tyrosine kinase inhibitors (TKIs) have greatly improved chronic myeloid leukemia (CML)
treatments, with survival rates close to the general population. Yet, for the very elderly …

Background Tyrosine kinase inhibitors (TKIs) have achieved revolutionary results in the
treatment of a wide range of tumors, and many studies on this topic continue to be published …

Background Recent years have witnessed the rapid evolution of therapies in chronic-phase
chronic myeloid leukemia (CP-CML). To assess the efficacy and tolerability of all reported …

Tyrosine kinase inhibitors (TKIs) that target BCR-ABL are the standard first-line therapy for
patients with chronic-phase CML. However, TKIs cannot eliminate quiescent leukemia stem …

The present study aimed to assess the clinical impact of BCR‐ABL 1 transcript levels
determined at an earlier time point than the 3‐month early molecular response (EMR) in …

Abstract Chronic Myeloid Leukaemia (CML) is a neoplastic disease which offshoot from
alterations in the Deoxyribonucleic Acid (DNA) of a specific bone marrow cell. It's a well …

Molecular laboratory investigations for myeloproliferative neoplasm (MPN) can ideally be
divided into two distincts groups, those for the detection of the BCR-ABL rearrangement …

Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase
chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early …