Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two diseases
that form a broad neurodegenerative continuum. Considerable effort has been made to …

Abstract Resveratrol (3, 4', 5-trihydroxystilbene; C 14 H 12 O 3) is a polyphenolic phytoalexin
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …

Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG
repeat expansion in HTT. Here we report correction of HD human induced pluripotent stem …

The architecture of cristae provides a spatial mitochondrial organization that contains
functional respiratory complexes. Several protein components including OPA1 and MICOS …

Alzheimer's disease (AD) is one of the most prevalent age-related neurodegenerative
diseases and accounts for the majority of dementia cases worldwide. Tremendous ongoing …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with
diverse functions in cellular physiology. In this regard, a large number of studies have …

The mitochondrial intermembrane space (IMS) is the most constricted sub-mitochondrial
compartment, housing only about 5% of the mitochondrial proteome, and yet is endowed …

Coiled-helix coiled-helix domain containing protein 10 (CHCHD10) and its paralogue
CHCHD2 belong to a family of twin CX9C motif proteins, most of which localize to the …