Histidine as a key modulator of molecular self-assembly: Peptide-based supramolecular materials inspired by biological systems
Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …
Supramolecular nanozymes based on peptide self-assembly for biomimetic catalysis
In diverse natural enzyme systems, their elegant properties and functions appeal to great
interest not only in unraveling the natural profound mystery but also in engineering the …
interest not only in unraveling the natural profound mystery but also in engineering the …
[HTML][HTML] Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics
Biomacromolecules are highly promising therapeutic modalities to treat various diseases.
However, they suffer from poor cellular membrane permeability, limiting their access to …
However, they suffer from poor cellular membrane permeability, limiting their access to …
[HTML][HTML] Biomolecular condensates formed by designer minimalistic peptides
A Baruch Leshem, S Sloan-Dennison… - Nature …, 2023 - nature.com
Inspired by the role of intracellular liquid-liquid phase separation (LLPS) in formation of
membraneless organelles, there is great interest in developing dynamic compartments …
membraneless organelles, there is great interest in developing dynamic compartments …
[HTML][HTML] Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis
Artificial organelles can manipulate cellular functions and introduce non-biological
processes into cells. Coacervate droplets have emerged as a close analog of …
processes into cells. Coacervate droplets have emerged as a close analog of …
Self‐stabilized supramolecular assemblies constructed from PEGylated dendritic peptide conjugate for augmenting tumor retention and therapy
X Zheng, D Pan, X Chen, L Wu, M Chen… - Advanced …, 2021 - Wiley Online Library
Supramolecular self‐assemblies of dendritic peptides with well‐organized nanostructures
have great potential as multifunctional biomaterials, yet the complex self‐assembly …
have great potential as multifunctional biomaterials, yet the complex self‐assembly …
Emergent properties of melanin-inspired peptide/RNA condensates
A Netzer, I Katzir, A Baruch Leshem… - Proceedings of the …, 2023 - National Acad Sciences
Most biocatalytic processes in eukaryotic cells are regulated by subcellular
microenvironments such as membrane-bound or membraneless organelles. These natural …
microenvironments such as membrane-bound or membraneless organelles. These natural …
Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing
Aromatic interactions are commonly involved in the assembly of naturally occurring building
blocks, and these interactions can be replicated in an artificial setting to produce functional …
blocks, and these interactions can be replicated in an artificial setting to produce functional …
[HTML][HTML] Supramolecular self-assembled peptide-based vaccines: current state and future perspectives
Despite the undeniable success of vaccination programs in preventing diseases, effective
vaccines against several life-threatening infectious pathogens such as human …
vaccines against several life-threatening infectious pathogens such as human …
Peptide Stereochemistry Effects from pKa-Shift to Gold Nanoparticle Templating in a Supramolecular Hydrogel
The divergent supramolecular behavior of a series of tripeptide stereoisomers was
elucidated through spectroscopic, microscopic, crystallographic, and computational …
elucidated through spectroscopic, microscopic, crystallographic, and computational …