Numerous studies have demonstrated a relationship between the extracellular matrix
protein BIGH3 and variations in the malignant properties of different cancer cell types …

Interest in the use of DNA nanotechnology in biomedical applications has increased
tremendously in the last decade due to the uniqueness of DNA properties that allow precise …

Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States.
It is identified by its rapid, invasive progression with a profound resistance to treatments such …

Scaffold-free tissue engineering approaches take advantage of cell–cell interactions,
specifically the phenomena of self-assembly and self-sorting. By using micro-molded …

The intra-tumoral delivery of drugs is long-standing challenge in cancer chemotherapy
because of complexity of the physiological barriers and biochemical mechanisms of tumor …

There is a large medical need for the development of effective anticancer agents with
minimal side effects. The present thesis represents an attempt to identify potent drugs for …

밝혀졌다.(1) 이에 다세포 스페로이드를 형성하는다양한 방법이 개발되었는데, 기존의 웰
플레이트및 플라스크를 이 한 스페로이드 형성방법 (2, 3) 은무혈관 (Avascular) 상태의 삼차원 …

The formation of embryoid bodies has long been utilized to initiate differentiation of
embryonic stem cells in vitro. The embryoid body provides an effective means of …

Nucleolin, an abundant cellular protein, has been recognized as a therapeutic target in gene
therapy treatments for cancer. Structural studies to facilitate rational design of small …

This thesis explored a novel way to engineer artificial multicellular structures combining
principles from tissue engineering, cell surface engineering and chemistry. Instead of using …