With the economy's globalization and the population's aging, cancer has become the
leading cause of death in most countries. While imposing a considerable burden on society …

Carbon‐heteroatom bond formation under transition‐metal free conditions provides a
powerful synthetic alternative for the efficient synthesis of valuable molecules. In particular …

T cell receptors (TCR) on cytolytic T lymphocytes (CTLs) recognize" foreign" antigens bound
in the groove of major histocompatibility complex (MHC) molecules (H-2 in mouse and HLA …

Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor
(TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated …

T-cell receptor (TCR) binding strength to peptide-MHC antigen complex influences
numerous T-cell functions. However, the vast diversity of a polyclonal T-cell repertoire for …

The use of aspirin is associated with reduced incidence of colorectal cancer (CRC).
However, the detailed mechanism remains unclear. In this study, we reported that colon …

Rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1D), and celiac disease
(CD), are strongly associated with susceptible HLA class II haplotypes. The peptide-binding …

Definition Small peptides are an important component of the vertebrate immune system.
They are important molecules for distinguishing proteins that originate in the host from …

Over the past few decades, research on cancer immunotherapy has firmly established
immune cells as key players in effective cancer treatment. Peptide vaccines directly targeting …

Few neoepitopes detected in tumor biopsies are immunogenic. Tumor-specific T cell
responses require both the presentation of an epitope that differs from wildtype and the …