Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157. Vascular recruitment and gastrointestinal tract healing

P Sikiric, R Rucman, B Turkovic… - Current …, 2018 - ingentaconnect.com
Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide
BPC 157, particular anti-ulcer peptide that heals different organs lesions when given as a …

[HTML][HTML] Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion

M Kolovrat, S Gojkovic, I Krezic… - World journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND The Pringle maneuver [portal triad obstruction (PTO)] provides huge
disturbances during ischemia and even more thereafter in reperfusion. Contrarily, a possible …

[HTML][HTML] Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

D Drmic, D Kolenc, S Ilic, L Bauk, M Sever… - World journal of …, 2017 - ncbi.nlm.nih.gov
METHODS Celecoxib (1 g/kg bw ip) was combined with therapy with stable gastric
pentadecapeptide BPC 157 (known to inhibit these lesions, 10 μg/kg, 10 ng/kg, or 1 ng/kg …

Therapy of the rat hemorrhagic cystitis induced by cyclophosphamide. Stable gastric pentadecapeptide BPC 157, L-arginine, L-NAME

M Sucic, K Luetic, I Jandric, D Drmic, AZ Sever… - European journal of …, 2019 - Elsevier
We focused on the cyclophosphamide-induced hemorrhagic cystitis (100 mg/kg/day
intraperitoneally throughout three days) as a particular NO-system disturbance, and therapy …

[HTML][HTML] Stable gastric pentadecapeptide BPC 157, Robert's stomach cytoprotection/adaptive cytoprotection/organoprotection, and Selye's stress coping response …

P Sikiric, KB Hahm, AB Blagaic, A Tvrdeic… - Gut and liver, 2020 - ncbi.nlm.nih.gov
We reviewed again the significance of the stable gastric pentadecapeptide BPC 157 as a
likely mediator of Robert's stomach cytoprotection/adaptive cytoprotection and …

BPC 157 therapy and the permanent occlusion of the superior sagittal sinus in rat: Vascular recruitment

S Gojkovic, I Krezic, H Vranes, H Zizek, D Drmic… - Biomedicines, 2021 - mdpi.com
We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and
lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and …

[HTML][HTML] Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats

S Gojkovic, I Krezic, B Vrdoljak… - World journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Recently, as a possible therapy resolving solution, pentadecapeptide BPC
157 therapy, has been used in alleviating various vascular occlusion disturbances. BPC 157 …

Occlusion of the superior mesenteric artery in rats reversed by collateral pathways activation: Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ …

M Knezevic, S Gojkovic, I Krezic, H Zizek… - Biomedicines, 2021 - mdpi.com
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction
syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to …

Effects of diclofenac, L-NAME, L-arginine, and pentadecapeptide BPC 157 on gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation …

N Lojo, Z Rasic, A Zenko Sever, D Kolenc, D Vukusic… - PLoS …, 2016 - journals.plos.org
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing
following major surgery and counteract diclofenac toxicity. To resolve the increasing early …

Therapy effect of the stable gastric pentadecapeptide BPC 157 on acute pancreatitis as vascular failure-induced severe peripheral and central syndrome in rats

IM Smoday, I Petrovic, L Kalogjera, H Vranes, H Zizek… - Biomedicines, 2022 - mdpi.com
We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg,
10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos …