The emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant …

N Zhang, K Quan, Z Chen, Q Hu, M Nie… - Emerging microbes & …, 2023 - Taylor & Francis
Vaccination is a crucial prevention and control measure against H9N2 avian influenza
viruses (AIVs) that threaten poultry production and public health. However, H9N2 AIVs in …

[HTML][HTML] Mutational antigenic landscape of prevailing H9N2 influenza virus hemagglutinin spectrum

J Zhang, X Wang, Y Chen, H Ye, S Ding, T Zhang… - Cell reports, 2023 - cell.com
H9N2 influenza viruses are globally endemic in birds, and a sharp increase in human
infections with H9N2 occurred during 2021 to 2022. In this study, we assess the antigenic …

MicroRNAs: exploring their role in farm animal disease and mycotoxin challenges

L Kappari, JR Dasireddy, TJ Applegate… - Frontiers in Veterinary …, 2024 - frontiersin.org
MicroRNAs (miRNAs) serve as key regulators in gene expression and play a crucial role in
immune responses, holding a significant promise for diagnosing and managing diseases in …

H9N2 avian influenza viruses: challenges and the way forward

J Zhang, L Huang, M Liao, W Qi - The Lancet Microbe, 2023 - thelancet.com
We read with interest the work of Yuhai Bi and colleagues1 and Rengui Yang and
colleagues, 2 published in The Lancet Microbe, describing that H9N2 avian influenza …

[HTML][HTML] Evolutionary Events Promoted Polymerase Activity of H13N8 Avian Influenza Virus

B Meng, Q Wang, H Leng, C Ren, C Feng, W Guo… - Viruses, 2024 - mdpi.com
Wild birds are considered to be the natural reservoir hosts of avian influenza viruses (AIVs).
Wild bird-origin AIVs may spill over into new hosts and overcome species barriers after …

[HTML][HTML] Virus Engineering and Applications

L Menotti - International Journal of Molecular Sciences, 2023 - mdpi.com
This Special Issue highlights multiple facets of virus engineering, ranging from the dissection
of the biological properties of individual viral functions in the context of safe genomic …

[HTML][HTML] Development of an inactivated avian influenza virus vaccine against circulating H9N2 in chickens and ducks

Y Liu, D Zhao, J Zhang, X Huang, K Han, Q Liu, J Yang… - Vaccines, 2023 - mdpi.com
Avian influenza virus (AIV) subtype H9N2 is the most widespread AIV in poultry worldwide,
causing great economic losses in the global poultry industry. Chickens and ducks are the …

[HTML][HTML] The mortality and years of life lost for community-acquired pneumonia before and during COVID-19 pandemic in China

G Fan, Y Zhou, F Zhou, Z Yu, X Gu, X Zhang… - The Lancet Regional …, 2024 - thelancet.com
Background Community-acquired pneumonia (CAP) is a leading cause of mortality
worldwide, but disease burden of CAP is not clear so far. We aim to explore the spatial and …

Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation

Y Zhi, X Zhao, Z Liu, G Shen, T Zhang, T Zhang, G Hu - Molecules, 2024 - mdpi.com
In our research, we explored a natural substance called Oxymatrine, found in a traditional
Chinese medicinal plant, to fight against a common bird flu virus known as H9N2. This virus …

[HTML][HTML] Bursal-derived BP7 induces the mirna molecular basis of chicken macrophages and promotes the differentiation of b cells

J Cai, Z Zhang, C Li, S Hao, A Lu, X Huang, X Feng - Vaccines, 2022 - mdpi.com
The bursa of Fabricius (BF) is a vital central humoral immune organ unique to birds. The
bioactive peptide BP7 derived from bursa is reported to promote the vaccine immune …