Aortic aneurysms are a common vascular disease in Western populations that can involve
virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than …

This review summarizes recent evidence concerning hormonal and sex chromosome effects
in obesity, atherosclerosis, aneurysms, ischemia/reperfusion injury, and hypertension …

There are many differences in arterial diseases between men and women, including
prevalence, clinical manifestations, treatments, and prognosis. The new policy of the …

Objective—Obesity promotes macrophage infiltration into adipose tissue and is associated
with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice …

Cardiovascular disease (CVD) remains a worldwide public health concern despite decades
of research and the availability of numerous targeted therapies. While the intrinsic …

A variety of animal models have been developed to better understand the pathophysiology
of AAA. The 3 most commonly used mouse AAA models are adventitial exposure to calcium …

Hyperhomocysteinemia (HHcy) is a risk factor for various cardiovascular diseases. However,
the mechanism underlying HHcy-aggravated vascular injury remains unclear. Here we show …

Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of
abdominal aortic aneurysms (AAAs). The purpose of this study was to define the contribution …

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due
to medial disruption and results in luminal dilation and thrombus formation. The objective of …

AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms)
through multiple proposed mechanisms, including chemotaxis. Therefore, we determined …