Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation,
and it has been studied extensively since its discovery in 2012. Induced by iron overload …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

Redox homeostasis is maintained by the antioxidant defense system, which is responsible
for eliminating a wide range of oxidants, including reactive oxygen species (ROS), lipid …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …