Trophoblast stem (TS) cells derived from the trophectoderm (TE) of mammalian embryos
have the ability to self-renew indefinitely or differentiate into fetal lineages of the placenta …

Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have
been investigated for polygenic overlap with Alzheimer's disease risk variants. We examined …

Embryonic genome activation is a critical event in embryo development, in which the
transcriptional program of the embryo is initiated. The timing and regulation of this process …

The pathophysiology of nonketotic hyperglycinemia (NKH), a rare neuro-metabolic disorder
associated with severe brain malformations and life-threatening neurological manifestations …

Methylation of histone 3 lysine 4 (H3K4) is largely associated with promoters and enhancers
of actively transcribed genes and is finely regulated during development by the action of …

A close cooperation between chromatin states, transcriptional modulation, and epigenetic
modifications is required for establishing appropriate regulatory circuits underlying self …

Aging, chronic inflammation, and environmental insults play an important role in a number of
disease processes through alterations of the epigenome. In this review we explore how age …

Stem cell fate determination is one of the central questions in stem cell biology, and
although its regulation has been studied at genomic and proteomic levels, a variety of …

Objectives Terminally differentiated stratified squamous epithelial cells play an important
role in barrier protection of the skin. The integrity of epidermal cells is maintained by tight …

Following fertilization of a mature oocyte, the formation of a diploid zygote involves a series
of coordinated cellular events that ends with the first embryonic mitosis. In animals, this …