Covering: 1964 to 2013 Natural products from bacteria and plants have played a leading
role in cancer drug discovery resulting in a large number of clinically useful agents. In …

Ionizing radiation (IR) plays an important role in the treatment of epithelial tumors, such as
lung and prostate cancer, by wounding and killing cancer cells. However, IR also activates …

In renal tissue injury, activation of the transcription factor NF-κB has a central role in the
induction of proinflammatory gene expression, which are involved in the development of …

Asian ginseng (AG) is the most commonly used medicinal herb in Asian countries. It is often
prescribed for cancer patients as a complementary remedy. However, whether AG in fact …

Radioresistance remains a major clinical challenge in cervical cancer therapy. However, the
mechanism for the development of radioresistance in cervical cancer is unclear. Herein, we …

A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV
gene expression in latently infected cells with latency reversal agents (LRAs) followed by …

Background and purpose MAPKs are among the most relevant signalling pathways involved
in coordinating cell responses to different stimuli. This group includes p38MAPKs …

Background and purpose Gemcitabine is an antitumour agent currently used in the
treatment of several types of cancer with known properties as a radiosensitizer. p38MAPK …

Current research suggests that synovial phagocytic cells remove excessive amounts of free
oxygen radicals (reactive oxygen species [ROS]), thereby preventing damage to synovial …

Simple Summary p38 MAPKs comprise a family of key proteins that regulate the stress
response of human cells, controlling relevant biological phenomena such as the cell cycle …