Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

The development of solid phase peptide synthesis has released tremendous opportunities
for using synthetic peptides in medicinal applications. In the last decades, peptide …

Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide
formats for drug design and discovery as they have the potential to combine the best …

Easy access to a wide range of structurally diverse stapled peptides is crucial for the
development of inhibitors of protein‐protein interactions. Herein, we report bis‐functional …

The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …

Over the past few decades, there has been a tremendous increase in the utilization of
therapeutic peptides. Therapeutic peptides are usually administered via the parenteral …

After the first seed concept introduced in the 18th century, different disciplines have
attributed different names to dual-functional molecules depending on their application …

A four‐membered oxygen ring (oxetane) can be readily grafted into native peptides and
proteins through site‐selective bis‐alkylation of cysteine residues present as disulfides …

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …