Aquaporin water channels in the nervous system

MC Papadopoulos, AS Verkman - Nature Reviews Neuroscience, 2013 - nature.com
The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

[HTML][HTML] Physiology of cholangiocytes

JH Tabibian, AI Masyuk, TV Masyuk… - Comprehensive …, 2013 - ncbi.nlm.nih.gov
Cholangiocytes are epithelial cells that line the intra-and extrahepatic ducts of the biliary
tree. The main physiologic function of cholangiocytes is modification of hepatocyte-derived …

Human aquaporins: functional diversity and potential roles in infectious and non-infectious diseases

AK Azad, T Raihan, J Ahmed, A Hakim, TH Emon… - Frontiers in …, 2021 - frontiersin.org
Aquaporins (AQPs) are integral membrane proteins and found in all living organisms from
bacteria to human. AQPs mainly involved in the transmembrane diffusion of water as well as …

The aquaporin-4 water channel as a potential drug target in neurological disorders

AS Verkman, AJ Smith, P Phuan… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …

Diversity and evolution of membrane intrinsic proteins

F Abascal, I Irisarri, R Zardoya - … et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Abstract Background Membrane intrinsic proteins (MIPs) are the proteins in charge of
regulating water transport into cells. Because of this essential function, the MIP family is …

Human aquaporin-5 facilitates hydrogen peroxide permeation affecting adaption to oxidative stress and cancer cell migration

C Rodrigues, C Pimpão, AF Mósca, AS Coxixo… - Cancers, 2019 - mdpi.com
Reactive oxygen species (ROS), including H2O2, contribute to oxidative stress and may
cause cancer initiation and progression. However, at low concentrations, H2O2 can regulate …

Chemokine-dependent T cell migration requires aquaporin-3–mediated hydrogen peroxide uptake

M Hara-Chikuma, S Chikuma, Y Sugiyama… - Journal of Experimental …, 2012 - rupress.org
Chemokine-dependent trafficking is indispensable for the effector function of antigen-
experienced T cells during immune responses. In this study, we report that the water/glycerol …

Disorders of erythrocyte hydration

PG Gallagher - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
The erythrocyte contains a network of pathways that regulate salt and water content in the
face of extracellular and intracellular osmotic perturbations. This allows the erythrocyte to …

Highlighting membrane protein structure and function: A celebration of the Protein Data Bank

F Li, PF Egea, AJ Vecchio, I Asial, M Gupta… - Journal of Biological …, 2021 - ASBMB
Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …

Water channel proteins in the gastrointestinal tract

U Laforenza - Molecular aspects of medicine, 2012 - Elsevier
Water transport through the human digestive system is physiologically crucial for
maintaining body water homeostasis and ensure digestive and absorptive functions. Within …