Publisher Summary The intent of the present chapter is to emphasize information about the
pharmacology of endothelin (ET) receptor antagonists and work relating to investigations …

To search for a possible role for endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-
salt-induced hypertension, we examined changes in concentration of ET-1 in vascular and …

We studied the expression of endothelin-1 (ET-1) receptors (ETA and ETB) and the effects of
ET-1 on cholangiocyte secretion. The effects of ET-1 on cholangiocyte secretion were …

To assess whether acute nitric oxide (NO) blockade could unmask the vascular actions of
endogenous endothelin, we tested the effects of the endothelin type A/type B (ETA/ETB) …

1 Inflammatory disease states predispose to myocardial infarction. Here we have
investigated the effects of a systemic inflammatory response syndrome, ie …

Endothelins (ETs) are peptides that produce potent and widespread effects in multiple
tissues and systems. Besides ET–1, its most prominent representative, this peptide family …

For investigation of whether interactions between prostaglandins and angiotensin II
modulate renal response to acute nitric oxide synthesis inhibition in humans, seven young …

Eight Na-repleted volunteers underwent 3 separate 90-minute infusions of either N G-nitro-l-
arginine methyl ester (L-NAME) 3.0 mg· kg− 1· min− 1 or endothelin-A receptor (ET-A) …

The effect of the endothelin ETA receptor antagonist on myocardial infarction was studied in
the rat. Under FR 139317anesthesia, rats were subjected to 30 min of left main coronary …

Background There is evidence that endothelin-1 (ET-1) increases extravasation of fluid and
protein into vascular beds. The present study was designed to determine the direct effects of …