Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Epithelial-mesenchymal transition (EMT) refers to a process in which epithelial cells lose
apical-basal polarity and loosen cell–cell junctions to take on mesenchymal cell …

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein–
based intracellular transport. Microtubule networks are highly diverse across different cell …

Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …

The phenomenon of planar cell polarity is critically required for a myriad of morphogenetic
processes in metazoan and is accurately controlled by several conserved modules. Six …

Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in
telomere maintenance leading to very short telomeres and the premature onset of certain …

Planar cell polarity (PCP) is essential for tissue morphogenesis and homeostasis; however,
the mechanisms that orchestrate the cell shape and packing dynamics required to establish …

VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue
polarity and patterning. The Vangl2 Lp mutation causes lung branching defects due to …

The molecular mechanisms by which cilia orientation is coordinated within and between
multi-ciliated cells (MCCs) are not fully understood. In the mouse oviduct, MCCs exhibit a …