The molecular mechanisms of systemic sclerosis-associated lung fibrosis

JE Mouawad, C Feghali-Bostwick - International journal of molecular …, 2023 - mdpi.com
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder that affects
the connective tissues and has the highest mortality rate among the rheumatic diseases …

The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?

M Ghanem, G Archer, B Crestani… - Pharmacology & …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease for which therapeutic
options are limited, with an unmet need to identify new therapeutic targets. IPF is thought to …

Inflammatory markers as predictors of Shunt Dependency and Functional Outcome in patients with Aneurysmal Subarachnoid Hemorrhage

N Rostgaard, MH Olsen, T Capion, N MacAulay… - Biomedicines, 2023 - mdpi.com
The mechanisms underlying post-hemorrhagic hydrocephalus (PHH) development following
subarachnoid hemorrhage (SAH) are not fully understood, which complicates informed …

Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

E Marchal-Duval, M Homps-Legrand, A Froidure… - Elife, 2023 - elifesciences.org
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells
driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of …

Progress in Understanding the Role and Therapeutic Targets of Polarized Subtypes of Macrophages in Pulmonary Fibrosis

Y Sun, H Xu, T Lu, T Li, Y Wang, X Fan, Y Jiang… - Cell Biochemistry and …, 2023 - Springer
Pulmonary fibrosis represents the advanced phase of diverse pulmonary ailments, and at
present, a definitive cure for these ailments is lacking. Furthermore, underlying mechanisms …

Identification and Validation of Genes Exhibiting Dynamic Alterations in Response to Bleomycin-Induced Pulmonary Fibrosis

D Li, J Wang, J Zeng, S Li, D Sun, L Qiu, Z Huang… - Molecular …, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) carries a high mortality rate and has a poor prognosis.
The pathogenesis of pulmonary fibrosis (PF) is highly related to dysregulation of multiple …

From the Gut to the Lung: Evidence of Antifibrotic Activity of Endocrine Fibroblast Growth Factor 19

RD Guzy, S Bollenbecker, S Krick - American Journal of Respiratory …, 2022 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is the most common and most severe form of pulmonary
fibrosis, a scarring disease of the lungs resulting in progressive lung stiffness and …

[PDF][PDF] Contemporary Concise Review 2022: Interstitial lung disease

DJF Smith, RG Jenkins - Respirology …, 2023 - avancesenfibrosispulmonar.com
Interstitial lung diseases (ILDs) are a group of conditions in which pulmonary tissue is
affected by abnormal cellular processes including inflammation, fibrosis or a combination of …

[HTML][HTML] Serum Fibroblast Growth Factor 19 as a Biomarker in Hepatitis B Virus-Related Liver Disease

X Miao, G Wu, X An, X Guo, C Peng - Hepatitis Monthly, 2022 - brieflands.com
Background: Past research has found that fibroblast growth factor 19 (FGF19) is associated
with several hepatic disorders, such as alcoholic liver disease and primary biliary cirrhosis …

Fibroblast growth factors (FGFs) endocrines et fibrogenèse pulmonaire

M Ghanem, A Mailleux, B Crestani - Revue des Maladies Respiratoires, 2023 - Elsevier
As key actors in embryogenesis and organogenesis, fibroblast growth factors (FGFs) can
assume a protective or an aggravative role in pulmonary fibrosis pathophysiology. Among …