The scale at which erectile dysfunction (ED) medicines are obtained outside of the official
health system rivals and possibly exceeds legitimate sales. According to literature a high …

Introduction: In 2013, riociguat a potent and specific stimulator of the soluble guanylyl
cyclase (sGC) was approved as first in class sGC stimulator which reflected a first …

Sulfoximines have gained considerable recognition as an important structural motif in drug
discovery of late. In particular, the clinical kinase inhibitors for the treatment of cancer …

Great attention has been paid to the clinical significance of phosphodiesterase 5 (PDE5)
inhibitors, such as sildenafil, tadalafil, and vardenafil widely used for erectile dysfunction …

Abstract Background/Objective Men do not use external condoms for several reasons, which
can result in public health problems. One of these is related to Condom-Associated Erectile …

The cyclic nucleotides (cN), cAMP and cGMP, are key second messengers that mediate the
intracellular effects of many signals known as “first messengers”, including environmental …

PDE5 belongs to a superfamily of enzymes that catalyzes the hydrolysis of cyclic nucleotides
cAMP and cGMP to the corresponding 5-nucleoside monophosphate. PDE5 takes part in …

A mechanistic understanding of the pathophysiology underpinning psychiatric disorders is
essential for the development of targeted molecular therapies. For fragile X syndrome (FXS) …

Alzheimer's Disease (AD) is a disease of synaptic dysfunction that ultimately proceeds to
neuronal death. There is a wealth of evidence that indicates the final common mediator of …

Drug repurposing has emerged as a promising approach in the drug discovery and
development process as it offers safe and effective therapeutic options in a time effective …