Artificial intelligence aids in development of nanomedicines for cancer management

P Tan, X Chen, H Zhang, Q Wei, K Luo - Seminars in cancer biology, 2023 - Elsevier
Over the last decade, the nanomedicine has experienced unprecedented development in
diagnosis and management of diseases. A number of nanomedicines have been approved …

Platinum resistance in ovarian cancer: role of DNA repair

G Damia, M Broggini - Cancers, 2019 - mdpi.com
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially
responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy …

Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: a real-world study

HM Wang, CY Zhang, KC Peng, ZX Chen, JW Su… - Cell Reports …, 2023 - cell.com
Predicting the clinical response to chemotherapeutic or targeted treatment in patients with
locally advanced or metastatic lung cancer requires an accurate and affordable tool. Tumor …

Advances in engineering human tissue models

CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …

Prevention and treatment of radiotherapy‐induced side effects

L Barazzuol, RP Coppes, P van Luijk - Molecular oncology, 2020 - Wiley Online Library
Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular Cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Identifying strategies to target the metabolic flexibility of tumours

A Méndez-Lucas, W Lin, PC Driscoll, N Legrave… - Nature …, 2020 - nature.com
Plasticity of cancer metabolism can be a major obstacle to efficient targeting of tumour-
specific metabolic vulnerabilities. Here, we identify the compensatory mechanisms following …

Flourishing tumor organoids: History, emerging technology, and application

Q Yang, M Li, X Yang, Z Xiao, X Tong… - Bioengineering & …, 2023 - Wiley Online Library
Malignant tumors are one of the leading causes of death which impose an increasingly
heavy burden on all countries. Therefore, the establishment of research models that closely …

Predictive biomarkers of response to neoadjuvant chemotherapy in breast cancer: current and future perspectives for precision medicine

F Derouane, C van Marcke, M Berlière, A Gerday… - Cancers, 2022 - mdpi.com
Simple Summary Despite the increased use of neoadjuvant chemotherapy in the early
setting of breast cancer, there is a clinical need for predictive markers of response in daily …

Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling

SK Kim, YH Kim, S Park, SW Cho - Acta biomaterialia, 2021 - Elsevier
As life expectancy improves and the number of people suffering from various diseases
increases, the need for developing effective personalized disease models is rapidly rising …