Sodium-glucose cotransporter 2 inhibitors and nephrolithiasis risk in patients with type 2 diabetes

JM Paik, H Tesfaye, GC Curhan, H Zakoul… - JAMA Internal …, 2024 - jamanetwork.com
Importance Type 2 diabetes (T2D) is associated with an increased risk of kidney stones.
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) might lower the risk of nephrolithiasis …

[HTML][HTML] Oxalate (dys) metabolism: Person-to-person variability, kidney and cardiometabolic toxicity

P Baltazar, AF de Melo Junior, NM Fonseca, MB Lança… - Genes, 2023 - mdpi.com
Oxalate is a metabolic end-product whose systemic concentrations are highly variable
among individuals. Genetic (primary hyperoxaluria) and non-genetic (eg, diet, microbiota …

[HTML][HTML] Pericyte detachment and renal congestion involve interstitial injury and fibrosis in Dahl salt-sensitive rats and humans with heart failure

H Ito, T Hirose, S Sato, C Takahashi, R Ishikawa… - Hypertension …, 2023 - nature.com
Congestive heart failure produces fluid volume overload, central and renal venous pressure
elevation, and consequently renal congestion, which results in worsening renal function …

Untargeted and targeted metabolomics reveal bile acid profile changes in rats with ethylene glycol-induced calcium oxalate nephrolithiasis

Z Zhou, D Feng, D Shi, P Gao, L Wang, Z Wu - Chemico-Biological …, 2023 - Elsevier
Calcium oxalate (CaOx) nephrolithiasis is a prevalent disorder linked to metabolism.
Examining metabolic alterations could potentially give an initial understanding of the origins …

[HTML][HTML] Impact of sodium-glucose cotransporter-2 inhibitors on urolithiasis

G Anan, D Kikuchi, T Hirose, H Ito, S Nakayama… - Kidney International …, 2023 - Elsevier
Results The current cross-sectional study used the Japanese administrative database
maintained by MDV analyzer (Medical Data Vision Co., Ltd., Tokyo, Japan), a web tool …

[HTML][HTML] Sodium glucose cotransporter 2 inhibitor suppresses renal injury in rats with renal congestion

A Endo, T Hirose, S Sato, H Ito, C Takahashi… - Hypertension …, 2024 - nature.com
Renal congestion is an issue of cardiorenal syndrome in patients with heart failure. Recent
clinical and basic studies suggest a renoprotective potential of sodium–glucose …

Quantitative effects of sodium-glucose cotransporter-2 inhibitors on liver functions in patients with nonalcoholic fatty liver disease

X Chen, C Xu, K Hu, Y Yang, YJ Zhang… - Expert Review of …, 2023 - Taylor & Francis
Background The present study aimed to explore the quantitative effects of sodium-glucose
cotransporter-2 (SGLT-2) inhibitors on liver functions in patients with nonalcoholic fatty liver …

[HTML][HTML] Sodium-glucose cotransporter-2 inhibitors increase urinary tract infections?—a cross sectional analysis of a nationwide Japanese claims database

G Anan, D Kikuchi, K Omae, T Hirose, K Okada… - Endocrine …, 2023 - jstage.jst.go.jp
Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of antidiabetic
drugs. Guidelines for the proper use of SGLT2 inhibitors recommend caution regarding …

The Association between Dietary Sugar Intake and Nephrolithiasis: Results from National Health and Nutrition Examination Survey 2007–2018

J Zhang, Z Tang, Z Lu, X Lin, H Liao, Z Li, W Chen… - The Journal of …, 2023 - Elsevier
Background Dietary sugar intake is gradually considered a risk factor for many diseases. A
sugary diet was positively associated with risk of nephrolithiasis, but the specific …

Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail diabetic elders with chronic kidney disease

P Mone, G Guerra, A Lombardi… - Pharmacological …, 2024 - pubmed.ncbi.nlm.nih.gov
Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail
diabetic elders with chronic kidney disease Effects of SGLT2 inhibition via empagliflozin on …