[HTML][HTML] Antigenic evolution of SARS coronavirus 2
AZ Mykytyn, RAM Fouchier, BL Haagmans - Current Opinion in Virology, 2023 - Elsevier
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in
December 2019. Vaccines developed were very effective initially, however, the virus has …
December 2019. Vaccines developed were very effective initially, however, the virus has …
[HTML][HTML] Evolution of the SARS-CoV-2 Omicron spike
RJ Parsons, P Acharya - Cell reports, 2023 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern, first identified in November 2021, rapidly spread worldwide and diversified into …
concern, first identified in November 2021, rapidly spread worldwide and diversified into …
[HTML][HTML] The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5
Summary Background Among the Omicron sublineages that have emerged, BA. 1, BA. 2,
BA. 5, and their related sublineages have resulted in the largest number of infections. While …
BA. 5, and their related sublineages have resulted in the largest number of infections. While …
[HTML][HTML] A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants
C Huang, H Shuai, J Qiao, Y Hou, R Zeng… - … and Targeted Therapy, 2023 - nature.com
Abstract Emerging SARS-CoV-2 variants, particularly the Omicron variant and its
sublineages, continually threaten the global public health. Small molecule antivirals are an …
sublineages, continually threaten the global public health. Small molecule antivirals are an …
Altered host protease determinants for SARS-CoV-2 Omicron
Successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
requires proteolytic cleavage of the viral spike protein. While the role of the host …
requires proteolytic cleavage of the viral spike protein. While the role of the host …
SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors
S Xia, L Wang, F Jiao, X Yu, W Xu… - Emerging Microbes & …, 2023 - Taylor & Francis
Continuous emergence of the Omicron variant, along with its subvariants, has caused an
increasing number of infections, reinfections, and vaccine-breakthrough infections, seriously …
increasing number of infections, reinfections, and vaccine-breakthrough infections, seriously …
[HTML][HTML] Emergence and antibody evasion of BQ, BA. 2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level
A Akerman, V Milogiannakis, T Jean, C Esneau… - …, 2023 - thelancet.com
Summary Background The Omicron era of the COVID-19 pandemic commenced at the
beginning of 2022 and whilst it started with primarily BA. 1, it was latter dominated by BA. 2 …
beginning of 2022 and whilst it started with primarily BA. 1, it was latter dominated by BA. 2 …
Determinants and mechanisms of the low Fusogenicity and high dependence on endosomal entry of omicron subvariants
The rapid spread and strong immune evasion of the SARS-CoV-2 Omicron subvariants has
raised serious concerns for the global COVID-19 pandemic. These new variants exhibit …
raised serious concerns for the global COVID-19 pandemic. These new variants exhibit …
[HTML][HTML] Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA. 2/5 subvariants in the upper and lower respiratory tract
Summary Background Earlier Omicron subvariants including BA. 1, BA. 2, and BA. 5
emerged in waves, with a subvariant replacing the previous one every few months. More …
emerged in waves, with a subvariant replacing the previous one every few months. More …
[HTML][HTML] SARS-CoV-2 Spike Protein Is Capable of Inducing Cell–Cell Fusions Independent from Its Receptor ACE2 and This Activity Can Be Impaired by Furin …
N Reuter, X Chen, B Kropff, AS Peter, WJ Britt, M Mach… - Viruses, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was responsible for
the COVID-19 pandemic, efficiently spreads cell-to-cell through mechanisms facilitated by its …
the COVID-19 pandemic, efficiently spreads cell-to-cell through mechanisms facilitated by its …