A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Integrase is an essential retroviral enzyme that binds both termini of linear viral DNA and
inserts them into a host cell chromosome. The structure of full-length retroviral integrase …

Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vDNA) copy of its RNA genome
into host target DNA (tDNA). The intasome, a higher-order nucleoprotein complex composed …

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration
complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 …

Integrase (IN) strand transfer inhibitors (INSTIs) have been developed to inhibit the ability of
HIV-1 integrase to irreversibly link the reverse-transcribed viral DNA to the host genome …

The intasome is the basic recombination unit of retroviral integration, comprising the
integrase protein and the ends of the viral DNA made by reverse transcription. Clinical …

Retroviral integrase (IN) functions within the intasome nucleoprotein complex to catalyze
insertion of viral DNA into cellular chromatin. Using cryo–electron microscopy, we now …

Abstract Background LEDGF/p75 (LEDGF) is the main cellular cofactor of HIV-1 integrase
(IN). It acts as a tethering factor for IN, and targets the integration of HIV in actively …

Integration of viral DNA into the host genome is a central event in the replication cycle and
the pathogenesis of retroviruses, including HIV. Although most cells infected with HIV are …