The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species

R Garcia-Rubio, HC de Oliveira, J Rivera… - Frontiers in …, 2020 - frontiersin.org
The fungal cell wall is located outside the plasma membrane and is the cell compartment
that mediates all the relationships of the cell with the environment. It protects the contents of …

Synthesis and assembly of fungal melanin

HC Eisenman, A Casadevall - Applied microbiology and biotechnology, 2012 - Springer
Melanin is a unique pigment with myriad functions that is found in all biological kingdoms. It
is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) …

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

SM Gonçalves, C Duarte-Oliveira, CF Campos… - Nature …, 2020 - nature.com
In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis
and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an …

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species

AM Andrianaki, I Kyrmizi, K Thanopoulou… - Nature …, 2018 - nature.com
Mucormycosis is a life-threatening respiratory fungal infection predominantly caused by
Rhizopus species. Mucormycosis has incompletely understood pathogenesis, particularly …

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence

T Heinekamp, A Thywißen, J Macheleidt… - Frontiers in …, 2013 - frontiersin.org
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two
types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin …

Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review

CA Croft, L Culibrk, MM Moore, SJ Tebbutt - Frontiers in microbiology, 2016 - frontiersin.org
Aspergillus fumigatus is an environmental filamentous fungus that also acts as an
opportunistic pathogen able to cause a variety of symptoms, from an allergic response to a …

[HTML][HTML] Fungal model systems and the elucidation of pathogenicity determinants

E Perez-Nadales, MFA Nogueira, C Baldin… - Fungal genetics and …, 2014 - Elsevier
Fungi have the capacity to cause devastating diseases of both plants and animals, causing
significant harvest losses that threaten food security and human mycoses with high mortality …

The innate immune response to Aspergillus fumigatus at the alveolar surface

A Margalit, K Kavanagh - FEMS microbiology reviews, 2015 - academic.oup.com
Aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne
conidia which are inhaled by humans on a daily basis. When the immune system is …

Interference of Aspergillus fumigatus with the immune response

T Heinekamp, H Schmidt, K Lapp, V Pähtz… - Seminars in …, 2015 - Springer
Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent
airborne fungal pathogen of humans. Depending on the host's immune status, the variety of …

The role of melanin in fungal pathogenesis for animal hosts

DFQ Smith, A Casadevall - Fungal physiology and immunopathogenesis, 2019 - Springer
Melanins are a class of pigments that are ubiquitous throughout biology. They play
incredibly diverse and important roles ranging from radiation protection to immune defense …