Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Highlights•IL-33 is a crucial activator of ILC2s in innate immunity and allergic
inflammation.•The gene encoding IL-33 is a major susceptibility locus for human asthma.•IL …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …

The pathogenesis of allergic rhinitis is associated with genetic, environmental, and
epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced …

An increasing proportion of the worldwide population is affected by allergic diseases such
as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment …

The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse
range of underlying dominant disease processes and pathways despite apparent similarities …

Background To date, no genome-wide association study (GWAS) has considered the
combined phenotype of asthma with hay fever. Previous analyses of family data from the …

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …