Phospholipid membranes as chemically and functionally tunable materials

D Huster, S Maiti, A Herrmann - Advanced Materials, 2024 - Wiley Online Library
The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …

Membrane transformations of fusion and budding

LG Wu, CY Chan - Nature Communications, 2024 - nature.com
Membrane fusion and budding mediate fundamental processes like intracellular trafficking,
exocytosis, and endocytosis. Fusion is thought to open a nanometer-range pore that may …

MXene/ZIF-L co-stacking membranes with high water permeation for solute-tailored selectivity

X Zhu, M Lou, J Chen, X Fang, S Huang, F Li - Applied Surface Science, 2023 - Elsevier
Herein, we design a composite MXene membrane with high permeability and stability by
introducing highly porous two-dimensional ZIF (zeolitic imidazolate framework)-L sheets. On …

Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection

HH Tsai, PH Huang, LCW Lin, BY Yao… - Advanced …, 2023 - Wiley Online Library
The highly conserved matrix protein 2 ectodomain (M2e) of influenza viruses presents a
compelling vaccine antigen candidate for stemming the pandemic threat of the mutation …

A Membrane Tension‐Responsive Mechanosensitive DNA Nanomachine

H Zheng, H Li, M Li, T Zhai, X Xie, C Li… - Angewandte Chemie …, 2023 - Wiley Online Library
Membrane curvature reflects physical forces operating on the lipid membrane, which plays
important roles in cellular processes. Here, we design a mechanosensitive DNA (MSD) …

Mesoscale simulation of biomembranes with FreeDTS

W Pezeshkian, JH Ipsen - Nature Communications, 2024 - nature.com
We present FreeDTS software for performing computational research on biomembranes at
the mesoscale. In this software, a membrane is represented by a dynamically triangulated …

Adhesion energy controls lipid binding-mediated endocytosis

R Groza, KV Schmidt, PM Müller, P Ronchi… - Nature …, 2024 - nature.com
Several bacterial toxins and viruses can deform membranes through multivalent binding to
lipids for clathrin-independent endocytosis. However, it remains unclear, how membrane …

Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

G Yin, J Huang, J Petela, H Jiang, Y Zhang… - … and Targeted Therapy, 2023 - nature.com
Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Shape Transformation of Polymer Vesicles

W Li, S Zhang, M Sun, S Kleuskens… - Accounts of Materials …, 2024 - ACS Publications
Conspectus Life activities, such as respiration, are accomplished through the continuous
shape modulation of cells, tissues, and organs. Developing smart materials with shape …

Molecular mechanism of GTP binding-and dimerization-induced enhancement of Sar1-mediated membrane remodeling

S Paul, A Audhya, Q Cui - Proceedings of the National …, 2023 - National Acad Sciences
The Sar1 GTPase initiates coat protein II (COPII)-mediated protein transport by generating
membrane curvature at subdomains on the endoplasmic reticulum, where it is activated by …