Targeting microbial biofilms: current and prospective therapeutic strategies

H Koo, RN Allan, RP Howlin, P Stoodley… - Nature Reviews …, 2017 - nature.com
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …

Review on multiple facets of drug resistance: a rising challenge in the 21st century

M Saha, A Sarkar - Journal of xenobiotics, 2021 - mdpi.com
With the advancements of science, antibiotics have emerged as an amazing gift to the
human and animal healthcare sectors for the treatment of bacterial infections and other …

Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments

WH Bowen, RA Burne, H Wu, H Koo - Trends in microbiology, 2018 - cell.com
Biofilms are microbial communities embedded within an extracellular matrix, forming a
highly organized structure that causes many human infections. Dental caries (tooth decay) is …

Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017 - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis

P Chakraborty, S Bajeli, D Kaushal, BD Radotra… - Nature …, 2021 - nature.com
Tuberculosis is a chronic disease that displays several features commonly associated with
biofilm-associated infections: immune system evasion, antibiotic treatment failures, and …

[PDF][PDF] Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

Development and regulation of single- and multi-species Candida albicans biofilms

MB Lohse, M Gulati, AD Johnson… - Nature Reviews …, 2018 - nature.com
Candida albicans is among the most prevalent fungal species of the human microbiota and
asymptomatically colonizes healthy individuals. However, it is also an opportunistic …

[HTML][HTML] Understanding the mechanism of bacterial biofilms resistance to antimicrobial agents

S Singh, SK Singh, I Chowdhury… - The open microbiology …, 2017 - ncbi.nlm.nih.gov
A biofilm is a group of microorganisms, that causes health problems for the patients with
indwelling medical devices via attachment of cells to the surface matrix. It increases the …

Nanomaterials for alternative antibacterial therapy

HA Hemeg - International journal of nanomedicine, 2017 - Taylor & Francis
Despite an array of cogent antibiotics, bacterial infections, notably those produced by
nosocomial pathogens, still remain a leading factor of morbidity and mortality around the …

Mechanisms of bacterial persistence during stress and antibiotic exposure

A Harms, E Maisonneuve, K Gerdes - Science, 2016 - science.org
BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable
infections caused by bacterial “superbugs.” However, many patients already suffer from …