The technology, opportunities and challenges of synthetic biological intelligence

BJ Kagan, C Gyngell, T Lysaght, VM Cole… - Biotechnology …, 2023 - Elsevier
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …

[HTML][HTML] Learning with three factors: modulating Hebbian plasticity with errors

Ł Kuśmierz, T Isomura, T Toyoizumi - Current opinion in neurobiology, 2017 - Elsevier
Highlights•The three-factor framework describes various learning rules in a unified
way.•Third factors can encode reward, attention, summary statistics, or supervised …

[HTML][HTML] In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

BJ Kagan, AC Kitchen, NT Tran, F Habibollahi… - Neuron, 2022 - cell.com
Integrating neurons into digital systems may enable performance infeasible with silicon
alone. Here, we develop DishBrain, a system that harnesses the inherent adaptive …

[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

L Smirnova, BS Caffo, DH Gracias, Q Huang… - Frontiers in …, 2023 - frontiersin.org
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …

Progressive tandem learning for pattern recognition with deep spiking neural networks

J Wu, C Xu, X Han, D Zhou, M Zhang… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
Spiking neural networks (SNNs) have shown clear advantages over traditional artificial
neural networks (ANNs) for low latency and high computational efficiency, due to their event …

[HTML][HTML] Canonical neural networks perform active inference

T Isomura, H Shimazaki, KJ Friston - Communications Biology, 2022 - nature.com
This work considers a class of canonical neural networks comprising rate coding models,
wherein neural activity and plasticity minimise a common cost function—and plasticity is …

[HTML][HTML] Experimental validation of the free-energy principle with in vitro neural networks

T Isomura, K Kotani, Y Jimbo, KJ Friston - Nature Communications, 2023 - nature.com
Empirical applications of the free-energy principle are not straightforward because they
entail a commitment to a particular process theory, especially at the cellular and synaptic …

[HTML][HTML] Neuronal message passing using Mean-field, Bethe, and Marginal approximations

T Parr, D Markovic, SJ Kiebel, KJ Friston - Scientific reports, 2019 - nature.com
Neuronal computations rely upon local interactions across synapses. For a neuronal
network to perform inference, it must integrate information from locally computed messages …

[HTML][HTML] The emergence of synchrony in networks of mutually inferring neurons

ER Palacios, T Isomura, T Parr, K Friston - Scientific reports, 2019 - nature.com
This paper considers the emergence of a generalised synchrony in ensembles of coupled
self-organising systems, such as neurons. We start from the premise that any self-organising …

An overview of in vitro biological neural networks for robot intelligence

Z Chen, Q Liang, Z Wei, X Chen, Q Shi… - Cyborg and Bionic …, 2023 - spj.science.org
In vitro biological neural networks (BNNs) interconnected with robots, so-called BNN-based
neurorobotic systems, can interact with the external world, so that they can present some …