[HTML][HTML] CA125 and ovarian cancer: a comprehensive review
Simple Summary CA125 has been the most promising biomarker for screening ovarian
cancer; however, it still does not have an acceptable accuracy in population-based …
cancer; however, it still does not have an acceptable accuracy in population-based …
Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer
M Zhang, S Cheng, Y Jin, Y Zhao, Y Wang - Biochimica et Biophysica Acta …, 2021 - Elsevier
After it was discovered approximately 40 years ago, carbohydrate antigen 125 (CA125)
became the most widely used and concerning biomarker in ovarian cancer screening …
became the most widely used and concerning biomarker in ovarian cancer screening …
[HTML][HTML] The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
The genomic landscape of breast cancer is complex, and inter-and intra-tumour
heterogeneity are important challenges in treating the disease. In this study, we sequence …
heterogeneity are important challenges in treating the disease. In this study, we sequence …
[HTML][HTML] MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress
M Felder, A Kapur, J Gonzalez-Bosquet, S Horibata… - Molecular cancer, 2014 - Springer
Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …
Cancer-associated mucins: role in immune modulation and metastasis
R Bhatia, SK Gautam, A Cannon, C Thompson… - Cancer and Metastasis …, 2019 - Springer
Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis.
However, their aberrant overexpression and glycosylation in various malignancies facilitate …
However, their aberrant overexpression and glycosylation in various malignancies facilitate …
MUC16 as a novel target for cancer therapy
Introduction: MUC16 is overexpressed in multiple cancers and plays an important role in
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …
tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe …
[HTML][HTML] Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
[HTML][HTML] Developing organoids from ovarian cancer as experimental and preclinical models
N Maenhoudt, C Defraye, M Boretto, Z Jan… - Stem Cell Reports, 2020 - cell.com
Ovarian cancer (OC) represents the most dismal gynecological cancer. Pathobiology is
poorly understood, mainly due to lack of appropriate study models. Organoids, defined as …
poorly understood, mainly due to lack of appropriate study models. Organoids, defined as …
[HTML][HTML] Significance of tumor mutation burden in immune infiltration and prognosis in cutaneous melanoma
K Kang, F Xie, J Mao, Y Bai, X Wang - Frontiers in oncology, 2020 - frontiersin.org
Background: Melanoma is highly immunogenic and therefore suitable for immunotherapy,
but the efficacy is limited by response rate. In several types of tumor, tumor mutation burden …
but the efficacy is limited by response rate. In several types of tumor, tumor mutation burden …
[HTML][HTML] Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics
Understanding the cellular composition of the tumor microenvironment and the interactions
of the cells is essential to the development of successful immunotherapies in cancer. We …
of the cells is essential to the development of successful immunotherapies in cancer. We …