The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

Next-generation sequencing (NGS) technologies are increasingly being used for diagnosis
and monitoring of infectious diseases. Herein, we review the application of NGS in clinical …

To curb HIV infection rate in Tanzania, antiretroviral therapy (ART) has been scaled up since
2006, and in 2019, the country shifted to regimen including dolutegravir as a default first line …

SUMMARY HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …

Background & Aims Shortened duration therapy for acute and recent HCV infection has
been shown to be highly effective in several small non-randomised studies with direct-acting …

Background Microelimination of hepatitis C virus (HCV) among people living with human
immunodeficiency virus (HIV) may be feasible in Australia, given unrestricted access to …

Objectives: To estimate the incidence of and risk factors for emergent resistance to integrase
strand transfer inhibitor (INSTI) and nucleoside (-tide) reverse transcriptase inhibitors (NRTI) …

Background WHO has developed a global HIV-drug resistance surveillance strategy,
including assessment of pretreatment HIV-drug resistance. We aimed to do a nationally …

Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug
resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been …

The ability of next-generation sequencing (NGS) technologies to detect low frequency HIV-1
drug resistance mutations (DRMs) not detected by dideoxynucleotide Sanger sequencing …