Targeting oxidative stress mechanisms to treat Alzheimer's and Parkinson's disease: a critical review
Neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease
(PD) are becoming more frequent as the age increases. Contemporary therapies provide …
(PD) are becoming more frequent as the age increases. Contemporary therapies provide …
Protective effects of Indian spice curcumin against amyloid-β in Alzheimer's disease
PH Reddy, M Manczak, X Yin… - Journal of …, 2018 - content.iospress.com
The purpose of our article is to assess the current understanding of Indian spice, curcumin,
against amyloid-ß (Aß)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural …
against amyloid-ß (Aß)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural …
[HTML][HTML] Ageing and Parkinson's disease: why is advancing age the biggest risk factor?
A Reeve, E Simcox, D Turnbull - Ageing research reviews, 2014 - Elsevier
As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …
disease, the health, social and economic impact resulting from Parkinson's disease will …
Mitochondrial quality control and disease: insights into ischemia-reperfusion injury
Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …
production of ATP that fuels cellular processes and, conversely, cell death via the induction …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal …
The purpose of our study was to determine the toxic effects of hippocampal mutant APP
(mAPP) and amyloid beta (Aβ) in human mAPP complementary DNA (cDNA) transfected …
(mAPP) and amyloid beta (Aβ) in human mAPP complementary DNA (cDNA) transfected …
Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria
Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …
PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease
Mitochondrial dysfunction and synaptic damage are early pathological features of the
Alzheimer's disease-affected brain. Memory impairment in Alzheimer's disease is a …
Alzheimer's disease-affected brain. Memory impairment in Alzheimer's disease is a …
Hypoxia, oxidative stress, and inflammation: three faces of neurodegenerative diseases
A Merelli, M Repetto, A Lazarowski… - Journal of Alzheimer's …, 2021 - content.iospress.com
The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a …
M Manczak, R Kandimalla, X Yin… - Human molecular …, 2018 - academic.oup.com
The purpose of our study was to determine the toxic effects of hippocampal mutant APP and
amyloid beta (Aβ) in 12-month-old APP transgenic mice. Using rotarod and Morris water …
amyloid beta (Aβ) in 12-month-old APP transgenic mice. Using rotarod and Morris water …