Abstract Purpose of Review To examine the effects and interactions between gut microbia
and chronic pain. Recent Findings The gut microbiome has been an area of interest in both …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in …

Previous studies have shown that activation of p38 mitogen-activating kinase (MAPK) in
spinal microglia participates in the generation of inflammatory and neuropathic pain in …

Increasing evidence suggests that spinal microglia regulate pathological pain in males. In
this study, we investigated the effects of several microglial and astroglial modulators on …

Increasing evidence indicates that the pathogenesis of neuropathic pain is mediated
through spinal cord microglia activation. The intracellular protease caspase-6 (CASP6) is …

We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …

Treatment with the chemotherapeutic agent oxaliplatin produces a robust painful neuropathy
similar to various other neuropathic conditions which result in loss of nerve fibers innervating …

Chronic systemic inflammation induces age-dependent differential phenotypic changes in
microglia and astrocytes, yielding an anti-inflammatory cell phenotype in young rats and a …

Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized
sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely …

Abstract Aims and methods Minocycline (Mino) and doxycycline (Dox) are second
generation tetracyclines known to present several other effects, which are independent from …