Background Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory
disorder associated with increased comorbid prevalence of cardiovascular diseases. We …

Background Cardiovascular disease (CVD) is common among patients with COPD.
However, it is not clear whether this is due to shared risk factors or if COPD increases the …

Abstract The Generation R Study is a population-based prospective cohort study from fetal
life until adulthood. The study is designed to identify early environmental and genetic causes …

Chronic obstructive pulmonary disease (COPD) is a global health issue with high social and
economic costs. Concomitant chronic cardiac disorders are frequent in patients with COPD …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

Background Smoking is a well-established risk factor for atherosclerotic disease, but its role
as an independent risk factor for venous thromboembolism (VTE) remains controversial. We …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background Clinical outcomes among COVID-19 patients vary greatly with age and
underlying comorbidities. We aimed to determine the demographic and clinical factors …

The prevalence of cardiovascular diseases is rising. Therefore, adequate risk prediction and
identification of its determinants is increasingly important. The Rotterdam Study is a …

Background Patients with COPD experience episodes of increased inflammation, so-called
acute exacerbations of COPD (AE-COPD). In 30% of AE-COPD cases, no clear cause is …