[HTML][HTML] Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Q Yan, S Liu, Y Sun, C Chen, S Yang, M Lin… - Journal of Translational …, 2023 - Springer
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

[HTML][HTML] Pyroptosis: a newly discovered therapeutic target for ischemia-reperfusion injury

Y Zheng, X Xu, F Chi, N Cong - Biomolecules, 2022 - mdpi.com
Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial
infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction …

[HTML][HTML] Tanshinone IIA inhibits cardiomyocyte pyroptosis through TLR4/NF-κB p65 pathway after acute myocardial infarction

R Chai, Z Ye, W Xue, S Shi, Y Wei, Y Hu… - Frontiers in cell and …, 2023 - frontiersin.org
Background: Tanshinone IIA, derived from Radix Salviae Miltiorrhizae (Salvia miltiorrhiza
Bunge), constitutes a significant component of this traditional Chinese medicine. Numerous …

Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola …

N Xing, J Qin, D Ren, Q Du, Y Li, J Mi, F Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacology relevance Rhodiola granules (RG) is a traditional Tibetan medicine
prescription that can be used to improve the symptoms of ischemia and hypoxia in …

[HTML][HTML] Storax Attenuates Cardiac Fibrosis following Acute Myocardial Infarction in Rats via Suppression of AT1R–Ankrd1–P53 Signaling Pathway

Z Xu, D Lu, J Yuan, L Wang, J Wang, Z Lei… - International Journal of …, 2022 - mdpi.com
Myocardial fibrosis following acute myocardial infarction (AMI) seriously affects the
prognosis and survival rate of patients. This study explores the role and regulation …

Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management

J Wang, J Zou, Y Shi, N Zeng, D Guo, H Wang, C Zhao… - Phytomedicine, 2024 - Elsevier
Background Cardiovascular disease (CVD) remains the leading cause of morbidity and
mortality worldwide, imposing an enormous economic burden on individuals and human …

Pyroptosis in myocardial ischemia/reperfusion and its therapeutic implications

Y Liu, X Li, T Sun, T Li, Q Li - European Journal of Pharmacology, 2024 - Elsevier
Ischemic heart disease, a prevalent cardiovascular disease with global significance, is
associated with substantial morbidity. Timely and successful reperfusion is crucial for …

[HTML][HTML] Metabolomic analysis reveals dynamic changes in secondary metabolites of Sophora japonica L. during flower maturation

JR Wang, XH Song, LY Li, SJ Gao, FH Shang… - Frontiers in Plant …, 2022 - frontiersin.org
Sophora japonica L. is widely consumed in China because of its medicinal and nutritional
value. Its quality is greatly affected by the accumulation of metabolites, which varies with the …

[HTML][HTML] Acidifiers attenuate diquat-induced oxidative stress and inflammatory responses by regulating NF-κB/MAPK/COX-2 pathways in IPEC-J2 cells

Q Xu, M Liu, X Chao, C Zhang, H Yang, J Chen… - Antioxidants, 2022 - mdpi.com
In this study, we evaluated the protective effects and potential mechanisms of acidifiers on
intestinal epithelial cells exposure to oxidative stress (OS). IPEC-J2 cells were first …

Serum Pharmacochemistry Combined with Network Pharmacology-Based Mechanism Prediction and Pharmacological Validation of Zhenwu Decoction on Alleviating …

R Li, L Zhu, M Wu, C Tao, Y Lu, Y Zhao, X Jiang… - ACS …, 2023 - ACS Publications
Zhenwu decoction (ZWD) is a famous classical formula in the treatment of heart failure (HF)
with significant clinical effects. Owing to the complex material basis of ZWD, it is challenging …