Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

Abstract Prostaglandin E 2 (PGE 2) is a bioactive lipid that elicits a wide range of biological
effects associated with inflammation and cancer. PGE 2 exerts diverse effects on cell …

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …

Chemoprevention has been considered as a possible approach for cancer prevention. A
significant effort has been made in the development of novel drugs for both cancer …

Background & Aims: Chronic inflammation is a risk factor for colon cancer in patients with
ulcerative colitis (UC). The molecular mechanisms linking inflammation and colon …

Central to the development of cancer are genetic changes that endow these “cancer cells”
with many of the hallmarks of cancer, such as self-sufficient growth and resistance to anti …

Background Cancer is a major burden of disease worldwide and increasing evidence shows
that inflammation contributes to cancer development and progression. Eicosanoids are …

Chronic inflammation is a risk factor for gastrointestinal cancer and other diseases. Most
studies have focused on cytokines and chemokines as mediators connecting chronic …