The evolution of SARS-CoV-2

PV Markov, M Ghafari, M Beer, K Lythgoe… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

SARS-CoV-2 biology and host interactions

S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Efficient evolution of human antibodies from general protein language models

BL Hie, VR Shanker, D Xu, TUJ Bruun… - Nature …, 2024 - nature.com
Natural evolution must explore a vast landscape of possible sequences for desirable yet
rare mutations, suggesting that learning from natural evolutionary strategies could guide …

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

SA Moghadasi, E Heilmann, AM Khalil, C Nnabuife… - Science …, 2023 - science.org
Vaccines and drugs have helped reduce disease severity and blunt the spread of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus …

Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution

W Ma, H Fu, F Jian, Y Cao, M Li - Nature Ecology & Evolution, 2023 - nature.com
Mutations in the SARS-CoV-2 genome could confer resistance to pre-existing antibodies
and/or increased transmissibility. The recently emerged Omicron subvariants exhibit a …

CRISPR-Cas13a-powered electrochemical biosensor for the detection of the L452R mutation in clinical samples of SARS-CoV-2 variants

Z Chen, C Wu, Y Yuan, Z Xie, T Li, H Huang… - Journal of …, 2023 - Springer
Since the end of 2019, a highly contagious disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has deprived numerous lives worldwide, called …

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

T Sanderson, R Hisner, I Donovan-Banfield, H Hartman… - Nature, 2023 - nature.com
Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during …

SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”

BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

The immune response to SARS-CoV-2 in people with HIV

MA Höft, WA Burgers, C Riou - Cellular & Molecular Immunology, 2024 - nature.com
This review examines the intersection of the HIV and SARS-CoV-2 pandemics. People with
HIV (PWH) are a heterogeneous group that differ in their degree of immune suppression …

[HTML][HTML] Insights for COVID-19 in 2023

FJM Sánchez, M Martínez-Sellés… - Revista Española de …, 2023 - ncbi.nlm.nih.gov
Predictions for a near end of the pandemic by the World Health Organization should be
interpreted with caution. Current evidence indicates that the efficacy of a fourth dose of …