Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Tau protein kinases: involvement in Alzheimer's disease
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy
M Perluigi, F Di Domenico, DA Butterfield - Neurobiology of disease, 2015 - Elsevier
Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
M Vreones, M Mustapic, R Moaddel, KA Pucha… - Aging …, 2023 - Wiley Online Library
Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging
contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of …
contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of …
The link between Alzheimer disease and metabolic syndrome: a mutual relationship and long rigorous investigation
HM Al-Kuraishy, MS Jabir, AK Albuhadily… - Ageing Research …, 2023 - Elsevier
It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital
growth, survival and metabolic functions in the brain. Here we describe specific and …
growth, survival and metabolic functions in the brain. Here we describe specific and …
The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target
J Sun, G Nan - International journal of molecular …, 2017 - spandidos-publications.com
Signaling pathways are critical modulators of a variety of physiological and pathological
processes, and the abnormal activation of some signaling pathways can contribute to …
processes, and the abnormal activation of some signaling pathways can contribute to …
Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
Alzheimer's disease: the two-hit hypothesis
There are many lines of evidence showing that oxidative stress and aberrant mitogenic
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …