Iron in multiple sclerosis: roles in neurodegeneration and repair

E Stephenson, N Nathoo, Y Mahjoub, JF Dunn… - Nature Reviews …, 2014 - nature.com
MRI and histological studies have shown global alterations in iron levels in the brains of
patients with multiple sclerosis (MS), including increases in the iron stored by macrophages …

Insight into the role of chondroitin sulfate E in angiogenesis

P Kastana, E Choleva, E Poimenidi… - The FEBS …, 2019 - Wiley Online Library
Chondroitin sulfate E (CS‐E) is a glycosaminoglycan containing type‐E disaccharide units
(sulfated at C‐4 and C‐6 of N‐acetylgalactosamine). CS‐E is covalently linked to a core …

Engineered sulfated polysaccharides for biomedical applications

Ø Arlov, D Rütsche, M Asadi Korayem… - Advanced Functional …, 2021 - Wiley Online Library
Sulfated polysaccharides are ubiquitous in living systems and have central roles in
biological functions such as organism development, cell proliferation and differentiation …

Keratan sulfate (KS)‐proteoglycans and neuronal regulation in health and disease: the importance of KS‐glycodynamics and interactive capability with …

J Melrose - Journal of Neurochemistry, 2019 - Wiley Online Library
Compared to the other classes of glycosaminoglycans (GAG s), that is, chondroitin/dermatan
sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known …

Chondroitin sulfate E alleviates β-amyloid toxicity in transgenic Caenorhabditis elegans by inhibiting its aggregation

X Wang, Y Yang, J Zou, Y Li, XG Zhang - International Journal of Biological …, 2022 - Elsevier
Abstract Chondroitin sulfate E (CS-E), which is characterized by oversulfated disaccharide
units, has been shown to regulate neuronal adhesion, neurite outgrowth and exert …

Enhancing the expression of chondroitin 4-O-sulfotransferase for one-pot enzymatic synthesis of chondroitin sulfate A

W Zhang, P Zhang, H Wang, R Xu, Z Xie, Y Wang… - Carbohydrate …, 2024 - Elsevier
Chondroitin sulfate (CS) stands as a pivotal compound in dietary supplements for
osteoarthritis treatment, propelling significant interest in the biotechnological pursuit of …

The sulfation of biomimetic glycosaminoglycan substrates controls binding of growth factors and subsequent neural and glial cell growth

W Malaeb, HF Bahmad, W Abou-Kheir… - Biomaterials …, 2019 - pubs.rsc.org
Sulfated glycosaminoglycans (GAGs) are key structural and functional extracellular matrix
(ECM) molecules involved in numerous signaling pathways mainly through their interaction …

Alginate sulfate substrates control growth factor binding and growth of primary neurons: Toward engineered 3D neural networks

G Kfoury, V El Habbaki, W Malaeb… - Advanced …, 2020 - Wiley Online Library
Sulfated glycosaminoglycans (sGAGs) are vital molecules of the extracellular matrix (ECM)
of the nervous system known to regulate proliferation, migration, and differentiation of …

Functions of chondroitin/dermatan sulfate containing GalNAc4, 6-disulfate

O Habuchi - Glycobiology, 2022 - academic.oup.com
Chondroitin sulfate (CS) and dermatan sulfate (DS) containing GalNAc4, 6-disulfate
(GalNAc4S6S) were initially discovered in marine animals. Following the discovery, these …

Chondroitin Sulfate Disaccharide Enhances Extracellular Matrix-Related Gene and Protein Expression in Normal Human Dermal Fibroblasts in Vitro

K KITAZAWA, S KANO, F HASHIMOTO… - 日本香粧品学会 …, 2015 - jstage.jst.go.jp
The physiological effects of chondroitin sulfate (CS) depend on the extent of its sulfation.
This study focused on the effects of highly sulfated CS with different molecular weights in …