Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for
the short-and long-term applications of medical devices such as cardiovascular stents …

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

The volume of extracellular fluid (ECF) is maintained within narrow limits in normal human
subjects, despite day-to-day variations in dietary intake of salt and water over a wide range …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Background and purpose: Inhibition of bradykinin metabolizing enzymes (BMEs) can cause
acute angioedema, as demonstrated in a recent clinical trial in patients administered the …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of
which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of …

Metabolomic studies have identified several metabolites associated with type 2 diabetes
(T2D) in populations of European ancestry. East Asians, a population of particular …