Leptin and obesity: role and clinical implication

M Obradovic, E Sudar-Milovanovic, S Soskic… - Frontiers in …, 2021 - frontiersin.org
The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

Pathophysiology of type 2 diabetes mellitus

U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

The role of adipokines in health and disease

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a
low-grade state of inflammation and different pathologies. The present review aims to …

Adipokines and obesity. Potential link to metabolic disorders and chronic complications

K Zorena, O Jachimowicz-Duda, D Ślęzak… - International journal of …, 2020 - mdpi.com
The World Health Organization (WHO) has recognized obesity as one of the top ten threats
to human health. It is estimated that the number of obese and overweight people worldwide …

Antioxidant and anti-inflammatory potential of polyphenols contained in mediterranean diet in obesity: Molecular mechanisms

A Nani, B Murtaza, A Sayed Khan, NA Khan, A Hichami - Molecules, 2021 - mdpi.com
Nutrition transition can be defined as shifts in food habits, and it is characterized by high-fat
(chiefly saturated animal fat), hypercaloric and salty food consumption at the expense of …

A review of obesity, physical activity, and cardiovascular disease

A Elagizi, S Kachur, S Carbone, CJ Lavie… - Current obesity reports, 2020 - Springer
Abstract Purpose of Review The focus of this review is to discuss obesity, physical activity
(and physical inactivity/sedentary behavior), cardiovascular disease (CVD), and their often …

[HTML][HTML] Mediterranean diet in the management and prevention of obesity

LJ Dominguez, N Veronese, G Di Bella… - Experimental …, 2023 - Elsevier
The current pandemic of obesity represents a major global public health problem, mainly
due to its association with chronic non-communicable disabling conditions and with …

Metabolic syndrome and psoriasis: mechanisms and future directions

Y Hao, Y Zhu, S Zou, P Zhou, Y Hu, Q Zhao… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is an immune-mediated systemic disease with associated comorbidities, including
metabolic syndrome (MetS) which contributes substantially to premature mortality in patients …

Time to consider the “exposome hypothesis” in the development of the obesity pandemic

V Catalán, I Avilés-Olmos, A Rodríguez, S Becerril… - Nutrients, 2022 - mdpi.com
The obesity epidemic shows no signs of abatement. Genetics and overnutrition together with
a dramatic decline in physical activity are the alleged main causes for this pandemic. While …