The genetics of obesity: from discovery to biology
The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
[PDF][PDF] Insights into modifiable risk factors of cholelithiasis: A Mendelian randomization study
L Chen, H Yang, H Li, C He, L Yang, G Lv - Hepatology, 2022 - Wiley Online Library
Abstract Background and Aims The risk factors of cholelithiasis have not been clearly
identified, especially for total cholesterol. Here, we try to identify these causal risk factors …
identified, especially for total cholesterol. Here, we try to identify these causal risk factors …
Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects
With the increasing availability of large-scale GWAS summary data on various complex traits
and diseases, there have been tremendous interests in applications of Mendelian …
and diseases, there have been tremendous interests in applications of Mendelian …
Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model
With the increasing availability of large-scale GWAS summary data on various traits,
Mendelian randomization (MR) has become commonly used to infer causality between a …
Mendelian randomization (MR) has become commonly used to infer causality between a …
Biochemical and cellular properties of insulin receptor signalling
RA Haeusler, TE McGraw, D Accili - Nature reviews Molecular cell …, 2018 - nature.com
The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: a soft clustering analysis
Background Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-
causing pathways are incompletely understood and (2) subclassification may improve …
causing pathways are incompletely understood and (2) subclassification may improve …
Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression
Growing evidence suggests that relative carbohydrate intake affects depression; however,
the association between carbohydrates and depression remains controversial. To test this …
the association between carbohydrates and depression remains controversial. To test this …
GWAS identifies 14 loci for device-measured physical activity and sleep duration
A Doherty, K Smith-Byrne, T Ferreira… - Nature …, 2018 - nature.com
Physical activity and sleep duration are established risk factors for many diseases, but their
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …
mechanisms underlying this link remain obscure. Using an integrative genomic approach …