Modulating neuroinflammation through molecular, cellular and biomaterial‐based approaches to treat spinal cord injury

CYP Lee, WH Chooi, SY Ng… - … & Translational Medicine, 2023 - Wiley Online Library
The neuroinflammatory response that is elicited after spinal cord injury contributes to both
tissue damage and reparative processes. The complex and dynamic cellular and molecular …

Nanoparticle-based delivery to treat spinal cord injury—a mini-review

A Chakraborty, AJ Ciciriello, CM Dumont… - AAPS PharmSciTech, 2021 - Springer
There is an increasing need to develop improved and non-invasive strategies to treat spinal
cord injury (SCI). Nanoparticles (NPs) are an enabling technology to improve drug delivery …

Immunomodulatory nanoparticles mitigate macrophage inflammation via inhibition of PAMP interactions and lactate-mediated functional reprogramming of NF-κB and …

JJM Lasola, AL Cottingham, BL Scotland, N Truong… - Pharmaceutics, 2021 - mdpi.com
Inflammation is a key homeostatic process involved in the body's response to a multitude of
disease states including infection, autoimmune disorders, cancer, and other chronic …

Development of protein–polymer conjugate nanoparticles for modulation of dendritic cell phenotype and Antigen-Specific CD4 T cell responses

BL Scotland, AL Cottingham, JJM Lasola… - ACS Applied Polymer …, 2023 - ACS Publications
Polymeric nanoparticles (NPs) composed of poly (lactic-co-glycolic acid)(PLGA) have found
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …

In vivo modulation of angiogenesis and immune response on a collagen matrix via extracorporeal shockwaves

D Heimes, N Wiesmann, J Eckrich, J Brieger… - International Journal of …, 2020 - mdpi.com
The effective management of tissue integration and immunological responses to transplants
decisively co-determines the success of soft and hard tissue reconstruction. The aim of this …

Targeting the oxytocinergic system: A possible pharmacological strategy for the treatment of inflammation occurring in different chronic diseases

M Friuli, B Eramo, M Valenza, C Scuderi… - International Journal of …, 2021 - mdpi.com
Unresolved inflammation represents a central feature of different human pathologies
including neuropsychiatric, cardiovascular, and metabolic diseases. The epidemiologic …

Hibiscus, rooibos, and yerba mate for healthy aging: A review on the attenuation of in vitro and in vivo markers related to oxidative stress, glycoxidation, and …

MT Nogueira Silva Lima, E Boulanger, FJ Tessier… - Foods, 2022 - mdpi.com
The world is currently undergoing a demographic change towards an increasing number of
elderly citizens. Aging is characterized by a temporal decline in physiological capacity, and …

[HTML][HTML] Modulatory effects of mushrooms on the inflammatory signaling pathways and pro-inflammatory mediators

A Rowaiye, OI Wilfred, OA Onuh, D Bur, S Oni… - Clinical Complementary …, 2022 - Elsevier
Background Mushrooms include a wide variety of bioactive compounds that have been
linked to therapeutic and nutritional benefits, making them a potential source of new …

Modulating mechanical and shape-memory properties while mitigating degradation-induced inflammation of polylactides by pendant aspirin incorporation

X Xu, J Zhang, TM Filion, A Akalin… - ACS applied materials & …, 2021 - ACS Publications
Synergistically modulating mechanical properties and improving shape-memory
performance while mitigating degradation-induced chronic inflammation of polylactide (PLA) …

[HTML][HTML] Size, surface charge and flexibility of vinegar-baked Radix Bupleuri polysaccharide affecting the immune response

X Wang, Y Zhao, Y Wu, L Liu, M Liang, M Han… - Arabian Journal of …, 2022 - Elsevier
Remarkably, nanomaterials can interact with the cells of immune system and either enhance
or inhibit its function in many ways. Unfortunately, such valuable information has been …