Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms

R Malaviya, HM Kipen, R Businaro, JD Laskin… - Toxicology and applied …, 2020 - Elsevier
Pulmonary fibrosis is characterized by destruction and remodeling of the lung due to an
accumulation of collagen and other extracellular matrix components in the tissue. This …

Disease‐modifying treatment of chemical threat agent–induced acute lung injury

J Radbel, DL Laskin, JD Laskin… - Annals of the New York …, 2020 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is a highly morbid lung pathology induced by
exposure to chemical warfare agents, including vesicants, phosgene, chlorine, and ricin. In …

Acute intensive care unit management of mustard gas victims: the Turkish experience

E Kilic, M Ortatatli, S Sezigen, RK Eyison… - Cutaneous and ocular …, 2018 - Taylor & Francis
Purpose: Sulphur mustard (SM) is an highly toxic and vesicant chemical weapon that was
used in various military conflicts several times in the history. The severity of ocular, dermal …

Acute corneal injury in rabbits following nitrogen mustard ocular exposure

DG Goswami, R Kant, DA Ammar, D Kumar… - … and molecular pathology, 2019 - Elsevier
Sulfur mustard (SM), a potent vesicating chemical warfare agent, and its analog nitrogen
mustard (NM), are both strong bi-functional alkylating agents. Eyes, skin, and the respiratory …

Progressive lung injury, inflammation, and fibrosis in rats following inhalation of sulfur mustard

R Malaviya, EV Abramova, RC Rancourt… - Toxicological …, 2020 - academic.oup.com
Sulfur mustard (SM) inhalation causes debilitating pulmonary injury in humans which
progresses to fibrosis. Herein, we developed a rat model of SM toxicity which parallels …

An Official American Thoracic Society Workshop Report: chemical inhalational disasters. Biology of lung injury, development of novel therapeutics, and medical …

EM Summerhill, GW Hoyle, SE Jordt… - Annals of the …, 2017 - atsjournals.org
This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly
sponsored by the American Thoracic Society (ATS) and the National Institutes of Health …

Mustard vesicant-induced lung injury: Advances in therapy

B Weinberger, R Malaviya, VR Sunil, A Venosa… - Toxicology and applied …, 2016 - Elsevier
Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to
pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the …

Advances in treatment of acute sulfur mustard poisoning–a critical review

L Etemad, M Moshiri, M Balali-Mood - Critical reviews in toxicology, 2019 - Taylor & Francis
Sulfur mustard (SM) is a blistering chemical warfare agent that was used during the World
War I and in the Iraq–Iran conflict. The aim of this paper is to discuss and critically review the …

Bronchiolitis obliterans and pulmonary fibrosis after sulfur mustard inhalation in rats

MD McGraw, MM Dysart, TB Hendry-Hofer… - American Journal of …, 2018 - atsjournals.org
Inhalation of powerful chemical agents, such as sulfur mustard (SM), can have debilitating
pulmonary consequences, such as bronchiolitis obliterans (BO) and parenchymal fibrosis …

TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation

S Achanta, NR Chintagari, M Brackmann… - Toxicology letters, 2018 - Elsevier
The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard
(SM) that initiates a delayed injury response characterized by erythema, inflammation and …