Naltrexone, a non-selective antagonist of opioid receptors, is mainly used as rehabilitation
therapy for discharged opiate addicts to eliminate addiction in order to maintain a normal life …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Objectives: First, to examine if LDN is associated with analgesic efficacy compared with
control in the treatment of patients with FM. Second, to ascertain the analgesic efficacy of …

Objective Our aim was to study the efficacy and mechanism by which NTX alleviate arthritis
in CIA rat models in vivo. Methods Female Wistar rats were randomly divided into 6 groups …

In recent years, low dose naltrexone (LDN) has been used as an off-label therapy for several
chronic diseases. Results from small laboratory and clinical studies indicate some beneficial …

Abstract Background and Aims Low-dose naltrexone [LDN] is a controversial off-label
treatment used by many Crohn's disease [CD] and ulcerative colitis [UC] patients. A small …

Low dose naltrexone (LDN) has become a popular off-label therapy for multiple sclerosis
(MS). A few small, randomized studies indicate that LDN may have beneficial effects in MS …

Opioids are highly effective analgesics, however, their therapeutic use is limited by adverse
effects that include respiratory depression, dependence, and tolerance. Inflammation has …

The opioid growth factor (OGF)–OGF receptor (OGFr) axis is present in normal and
abnormal cells and tissues, and functions to maintain homeostatic cell replication. OGF is an …

Abstract Background and Objective Cytochrome P450 (CYP) 1A2, 2C9, 2D6, and 3A4 are
the most important phase I drug-metabolizing enzymes in the liver, but there is a dearth of …