Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury

QM Chen - Free Radical Biology and Medicine, 2022 - Elsevier
Myocardial infarction is the most common form of acute coronary syndrome. Blockage of a
coronary artery due to blood clotting leads to ischemia and subsequent cell death in the form …

Involvement of Nrf2 in myocardial ischemia and reperfusion injury

Y Shen, X Liu, J Shi, X Wu - International journal of biological …, 2019 - Elsevier
The morbidity rate of myocardial ischemia and reperfusion has increased in modern society,
and oxidative stress plays a critical role in the pathological process. Nuclear factor E2 …

Oxidative stress in ischemic heart disease

A Kibel, AM Lukinac, V Dambic, I Juric… - Oxidative medicine …, 2020 - Wiley Online Library
One of the novel interesting topics in the study of cardiovascular disease is the role of the
oxidation system, since inflammation and oxidative stress are known to lead to …

Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications

N Apostolova, VM Victor - Antioxidants & redox signaling, 2015 - liebertpub.com
Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …

[HTML][HTML] Mechanisms of gene regulation by fatty acids

A Georgiadi, S Kersten - Advances in nutrition, 2012 - Elsevier
Consumption of specific dietary fatty acids has been shown to influence risk and progression
of several chronic diseases, such as cardiovascular disease, obesity, cancer, and arthritis. In …

Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment

RK McNamara, W Kalt, MD Shidler, J McDonald… - Neurobiology of …, 2018 - Elsevier
Given evidence that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and
anthocyanin-rich blueberries provide neurocognitive benefit, we investigated long-term …

Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

S Davinelli, A Medoro, M Intrieri, L Saso… - Free Radical Biology …, 2022 - Elsevier
The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …

Lipid oxidation derived aldehydes and oxysterols between health and disease

B Sottero, G Leonarduzzi, G Testa… - European journal of …, 2019 - Wiley Online Library
Non‐enzymatic and enzymatic oxidation of lipids has long been a primary issue in human
pathophysiology, with special emphasis on diet‐and nutrition‐related aspects. While there is …

Fatty acid signaling: the new function of intracellular lipases

Z Papackova, M Cahova - International journal of molecular sciences, 2015 - mdpi.com
Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid
droplets have been considered to be only passive “energy conserves”. Nevertheless …

High dietary fat selectively increases catalase expression within cardiac mitochondria

PM Rindler, SM Plafker, LI Szweda, M Kinter - Journal of Biological …, 2013 - ASBMB
Obesity is a predictor of diabetes and cardiovascular disease. One consequence of obesity
is dyslipidemia characterized by high blood triglycerides. It has been proposed that oxidative …