Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental
and clinical interest. Using quantitative interactomics, we define the composition and …

T‐cell development in the thymus and activation of mature T cells in secondary lymphoid
organs requires the ability of cells to respond appropriately to environmental signals at …

Tyrosine phosphorylation and dephosphorylation of proteins play a critical role for many T‐
cell functions. The opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine …

T-lymphocyte activation displays a remarkable combination of speed, sensitivity, and
discrimination in response to peptide–major histocompatibility complex (pMHC) ligand …

T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box
p3+ (Foxp3+) regulatory T cells. Several lines of evidence indicate that weak TCR …

Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …

Serum IgA is considered a discrete housekeeper of the immune system with multiple anti-
inflammatory functions, whereas IgA-immune complexes mediate inflammatory responses …

The immunological synapse is a specialized cell-cell junction between T cell and antigen-
presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of …

Heterogeneity in the natural killer (NK) cell population is determined by variegated
expression of polygenic and polymorphic receptors and distinct phenotypes and functions of …

In T cells, the stochasticity of protein expression could contribute to the useful diversification
of biological functions within a clonal population or interfere with accurate antigen …