Systems biology is an emerging discipline that combines high-content, multiplexed
measurements with informatic and computational modeling methods to better understand …

Activation of the transcription factor NF-κB after engagement of the T cell receptor (TCR) is
important for T cell proliferation and activation during the adaptive immune response …

Antigen stimulation of T cell receptor (TCR) signaling to nuclear factor (NF)-κB is required for
T cell proliferation and differentiation of effector cells. The TCR-to-NF-κB pathway is …

Immune homeostasis is regulated by a finely tuned network of positive–negative regulatory
mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to …

Engagement of the T cell receptor (TCR) by stimulatory ligand results in the rapid formation
of microclusters at sites of T cell activation. Whereas microclusters have been studied …

The ability of CD4+ T cells to differentiate into effector subsets underpins their ability to
shape the immune response and mediate host protection. During T cell receptor-induced …

The process of signalling through receptors of the immune system involves highly connected
networks of interacting components. Understanding the often counter-intuitive behaviour of …

The thymus generates major histocompatibility complex (MHC)-restricted αβT cells that only
recognize antigenic ligands in association with MHC or MHC-like molecules. We …

T cells recognize a few high-affinity antigens among a vast array of lower affinity antigens.
According to the kinetic proofreading model, antigen discrimination properties could be …

Tyrosyl phosphorylation plays a critical role in multiple signaling pathways regulating innate
and acquired immunity. Although tyrosyl phosphorylation is a reversible process, we know …